Abstract
The cultivation of sugarcane hybrids (X Saccharum officinarum L.) is an important revenue source for the Brazilian economy. Herein it is reported the evaluation of the cytotoxic activity of mid-polarity sugarcane extracts against human cancer cell lines, as well as the isolation of steroids sitosterol, stigmasterol and campesterol, phenolic acids p-hydroxybenzoic, p-hydroxycinnamic, vanillic and ferulic acid, terpenoids α-tocopherol and β-carotene and a novel substance in sugarcane, the flavonoid aglycone tricin (5,7,4-trihydroxy-3,5-dimethoxyflavone). The presence of large amounts of phenolic acids and the flavonoid tricin may explain the cytostatic activity observed for the mid-polarity crude extract and filtrates.
Highlights
Sugarcane (Saccharum officinarum L., Poaceae), a grass native to Asia, is widely found in tropical regions and it is one of the most important cultures in Brazil, with an annual production of over 375 million tons (Conab 2013)
The most common phenolic compounds found in S. officinarum belong to the flavone class, such as naringenin, apigenin, tricin and luteolin derivatives (Williams et al 1974, López-Lázaro 2009)
These compounds are partly responsible for the sugarcane juice color and are acknowledged to have beneficial health effects associated with their high antioxidant potential and capacity to protect cells from degenerative processes and reduce the development of cancer and cardiovascular diseases
Summary
Sugarcane (Saccharum officinarum L., Poaceae), a grass native to Asia, is widely found in tropical regions and it is one of the most important cultures in Brazil, with an annual production of over 375 million tons (Conab 2013). The antiproliferative activity of the ethyl acetate extract and fractions and the isolation of chemical constituents from the leaves of S. officinarum commercially cultivated in Brazil are reported .
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