Phenolic Acid Derivatives, Flavonoids and Other Bioactive Compounds from the Leaves of Cardiocrinum cordatum (Thunb.) Makino (Liliaceae).

Kengo Hori,Hari Prasad Devkota,Takashi Watanabe

doi:10.3390/plants10020320

Kengo Hori, Hari Prasad Devkota + Show 1 more

Open Access

https://doi.org/10.3390/plants10020320

Copy DOI

Abstract

Cardiocrinum cordatum (Thunb.) Makino (Family: Liliaceae), commonly known as ‘Ubayuri’, is native to Japan and some islands in the Russian Far East. It has high value as food, medicinal, and ornamental species. The aim of this study was to isolate and characterize the main chemical constituents of the leaves of C. cordatum. A total of 19 compounds, namely caffeic acid (1), caffeic acid methyl ester (2), caffeic acid β-glucopyranosyl ester (3), caffeic acid 4-O-β-glucopyranoside (4), ferulic acid (5), isoferulic acid (6), protocatechuic acid (7), syringic acid (8), 2,6-dimethoxy-p-hydroquinone 1-O-β-glucopyranoside (9), esculetin (10), taxifolin (11), quercetin 3-O-(6-O-α-rhamnopyranosyl)β-glucopyranoside-7-O-β-rhamnopyranoside (12), 2,7-dimethyl-2,4-diene-deca-α,ω-diacid β-glucopyranoside (13), 4-[formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]butanoic acid (14), (3Z)-3-hexenyl β-glucopyranoside (15), tryptophan (16), adenine (17), adenosine (18), and 2-deoxyadenosine (19) were isolated using various chromatographic methods. The structures of isolated compounds were elucidated on the basis of their NMR spectroscopic data. All these compounds were isolated for the first time from the genus Cardiocrinum. Phenolic acid derivatives and flavonoids can be considered as chemotaxonomic markers in the leaves of Cardiocrinum species.

Highlights

Accepted: 5 February 2021The genus Cardiocrinum (Liliaceae) comprises of three perennial bulbiferous herb species, C. cathayanum
Some previous studies reported the flavonoids from the seeds of C. giganteum [9,10,11] and the starch composition of the bulbs of C. cordatum var. glehnii (F.Schmidt) H.Hara [7,8]
The dried young leaves of C. cordatum were extracted with methanol (MeOH) and the extract was subjected to repeated column chromatography on MCI gel CHP20P, the extract was subjected to repeated column chromatography on MCI gel CHP20P, Sephadex LH-20, ODS and silica gel to isolate 19 pure compounds

Summary

Introduction

Accepted: 5 February 2021The genus Cardiocrinum (Liliaceae) comprises of three perennial bulbiferous herb species, C. cathayanum Cardiocrinum cordatum (Figure 1), commonly known as ‘Ubayuri’ in Japan, is native to Japan and some islands in the Russian Far East [1,5]. It is a perennial herb with the height of about 60–100 m. The Cardiocrinum species have high value as food, medicinal, and ornamental plants [4,6], only a few studies have been performed regarding their chemical constituents. Some previous studies reported the flavonoids from the seeds of C. giganteum [9,10,11] and the starch composition of the bulbs of C. cordatum var. The main aim of this study was to isolate and identify the major chemical constituents of the leaves of C. cordatum

Objectives

Methods

Results

Conclusion