Abstract
In a survey of the active components of crude plant extracts for their ability to cleave DNA, a crude extract prepared from Piper caninum was found to induce the relaxation of supercoiled pBR322 plasmid DNA in the presence of Cu 2+. Bioassay-guided fractionation was carried out on this extract, guided by an in vitro DNA strand scission assay. Three active principles were isolated and identified as N- cis-feruloyl tyramine ( 1), N- trans-feruloyl tyramine ( 2), and 1-cinnamoylpyrrolidine ( 3). Compounds 1– 3 represent a structurally new type of DNA strand scission agent.
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