Abstract
Both phenobarbitone and methysergide produce a decrease of the thialbarbitone sleeping time in gamma-irradiated rats. Phenobarbitone was injected 2 and 48 hr after irradiation with 600 r and 800 r. The effect of phenobarbitone was found to be maximal 48 hr after its injection, and it was evident only in rats irradiated with 600 r. Methysergide was also injected 2 and 48 hr after irradiation and this procedure was found not to affect the thialbarbitone sleeping time. On the contrary, methysergide significantly depressed the thialbarbitone sleeping time if injected 15–30 min before thialbarbitone. This effect of methysergide is present only in irradiated animals. Ethionine, if injected 15 min before methysergide, inhibited the action of methysergide on the thialbarbitone sleeping time. This effect of ethionine was not blocked by methionine. It is suggested that phenobarbitone and methysergide affect the thialbarbitone sleeping time either by different mechanisms, or by similar mechanisms in which time factor is different.
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