Abstract
Phenethylisothiocyanate (PEITC) applied as a synthetic compound or as a botanical formulation (Barbarea verna seed preparations, BSP) is capable of suppressing in vitro expression of the pro-inflammatory genes in a concentration dependent manner at the mRNA level. The in vitro activity of PEITC, in lipopolysaccharide (LPS)-stimulated mouse macrophage cell line RAW 264.7, was compared to that of two nonsteroidal anti-inflammatory drugs (NSAID)- aspirin and rofecoxib. PEITC was the most active out of five forms of isothiocyanate tested, in terms of inhibiting inflammation-related gene expression. In vivo, BSP had strong anti-inflammatory activity, significantly reducing the size of carrageenan-induced rat paw edema. The in vivo effect was comparable to that of aspirin. We conclude that BSP may function as an antiinflammatory agent.
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