Abstract
The facilitatory or inhibitory effect of paradoxical sleep (PxS) was investigated in two models of focal epilepsy: focal motor seizures induced by alumina cream in the frontal cortex and limbic seizures produced by intra-amygdaloid kainic acid microinjections in cats. We found that phasic episodes of PxS could trigger both types of seizures. Interictal spikes were generally blocked during PxS. We conclude that PxS exerts facilitatory or inhibitory effects depending on the particular event under analysis and the degree of epileptogenicity. The capacity of phasic PxS to precipitate focal ictal discharges may depend on pontolimbic excitatory influences.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.