Phase-dependent chronotropic response of the heart during running in humans

Abstract

Heartbeat modulation by muscle contraction during rhythmic exercise involving a small muscle mass is phase-dependent, reflecting the timing of the muscle contraction within the cardiac cycle, but it remains unclear whether such modulation occurs during whole body exercise. To determine whether phase-dependent chronotropic changes in the heart would occur during running, we investigated the relationship between R-R interval (RRI) and the timing of vastus lateralis muscle contractions within the cardiac cycle. Seven healthy subjects were examined during high intensity running where the target heart rate was 160 beats . min(-1). The running pitch was made to wax and wane periodically in the neighborhood of the target heart rate to scan the effect of footfall timing within the cardiac cycle on heart period. We found that when muscle contraction occurred early in the cardiac cycle, RRI was reduced from the mean RRI (P<0.05). Conversely, when muscle contraction occurred in the latter half of the cardiac cycle, RRI tended to increase (P>0.05). Thus, the curve reflecting this phase-dependent relationship between heart period and timing of muscle contraction showed a positive slope within the first one-quarter to three-quarters of the cardiac cycle. Our results suggest the existence of a mechanism that provides beat-by-beat regulation of RRI even when it is very short (approximately 375 ms), i.e., a cardio-locomotor synchronization develops during running, when the frequencies of the two rhythms approach one another.