Abstract
The interaction between a series of condensed aromatic hydrocarbons of different size and shape (with and without carcinogenic activity) with dipalmitoyl lecithin bilayers was investigated by the spin label method. The spectra of a cholestane spin probe in the bilayers were examined. The smaller non-carcinogenic hydrocarbons did not alter the degree of organization of the phospholipid molecules to a large extent. On the other hand, large, carcinogenic aromatic hydrocarbons interacted with the bilayers, promoting a gel to liquid crystal phase transition. These data indicate that the two types of molecules interact with the membrane in different ways.
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More From: Biochemical and Biophysical Research Communications
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