PHASE TRANSFER CATALYTIC SYNTHESIS OF SILYL DERIVATIVES OF HETEROCYCLIC THIOLS

Abstract

Reactions of heteroaromatic thiols with trialkylsilylalkyl iodides in the two-phase catalytic system (solid K 2 CO 3 /18-crown-6/toluene) at 111°C selectively lead to formation of the corresponding (trialkylsilylalkyl)thiohetarenes. 6-Mercaptopurine in the presence of two equivalents of alkylating agent yields S,N-dialkylated derivatives. Authors: E. Abele, K. Rubina, R. Abele, I. Sleiksha, and E. Lukevics. English Translation in Chemistry of Heterocyclic Compounds , 1999, 35 (9), pp 1052-1058 http://link.springer.com/article/10.1007/BF02251796