Phase‐Transfer‐Catalyst‐Mediated Domino Reaction of γ‐Nitro Ketones with Chalcones: Approach to Functionalized Six‐Membered‐Ring Carbocycles

Abstract

AbstractDomino reactions between γ‐nitro ketones and chalcones for the construction of functionalized six‐membered‐ring carbocycles using a phase‐transfer catalyst have been developed. In the presence of tetrabutylammonium iodide and potassium hydroxide, domino reactions between γ‐nitro ketones and a series of chalcones proceeded smoothly to give the cyclic products in moderate to high yields with high diastereoselectivities. Importantly, multiply substituted and functionalized six‐membered‐ring carbocycles could be efficiently prepared in one pot using this domino strategy.