Abstract
Various 3,4-dihydropyrimidinones can be prepared via Biginelli reaction in aqueous media by using quaternary ammonium salts of different alkyl groups (C4 and C8) and anions (Cl- and Br-) as catalysts. The use of quaternary ammonium salts along with longer alkyl chains increases the yield of the Biginelli reaction; however, bromide ammonium salts are less active than the chloride ones.
Highlights
Multicomponent reaction [1,2,3] is defined as the process in which three or more reactants are combined in one step
We have reported the synthesis of dihydropyrimidinones by Biginelli reaction in aqueous sodium hydroxide under phase transfer catalysis using tetrabutylammonium bromide (TBAB) or chloride (TBAC) or methyltrioctylammonium chloride (Aliquat-336) as phase transfer agent
We have under taken the synthesis of different derivatives of 3,4-dihydropyrimidinones by three component one-pot Biginelli condensation of an aldehyde, ethyl acetoacetate and urea (Scheme 1)
Summary
Multicomponent reaction [1,2,3] is defined as the process in which three or more reactants are combined in one step These reactions are of great interest and of great importance in organic synthesis and medicinal chemistry because they offer direct access to complex molecules [4,5,6,7,8,9,10]. In this context, the Biginelli reaction, discovered by Biginelli [11], is a multi-component reaction that involves the cyclocondensation of aldehyde. We have reported the synthesis of dihydropyrimidinones by Biginelli reaction in aqueous sodium hydroxide under phase transfer catalysis using tetrabutylammonium bromide (TBAB) or chloride (TBAC) or methyltrioctylammonium chloride (Aliquat-336) as phase transfer agent
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