Abstract
This article describes the use of poly(carbamate) oligomers that depolymerize from head-to-tail as phase-switching reagents for increasing the sensitivity of quantitative point-of-care assays that are based on measurements of time. The poly(carbamate) oligomers selectively react with hydrogen peroxide (a model analyte) and provide sensitivity by depolymerizing in the presence of the analyte to convert from water-insoluble oligomers to water-soluble products. This switching reaction enables a sample to wick through a three-dimensional paper-based microfluidic device, where the flow-through time reflects the quantity of the analyte in the sample. Oligomers as short as octamers enable quantitative detection to low nanomolar concentrations of the analyte.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
