Abstract
During ontogeny, in rat liver, enzymes are synthesized in clusters characteristic of specific periods of development. These spurts of activity occur in well‐defined late‐term, neonatal and late suckling periods. To test the hypothesis that malignant transformation is associated with a synchronous arrest in differentiation or by an orderly, stepwise process of dedifferentiation and might therefore be characterized by the presence of an enzyme pattern typical of a specific phase of development, we examined enzyme profiles in the Morris 5123 hepatoma and two of its variants (1–1 and 81‐B), a solid tumor derived from HTC cells and a DEN‐AAF induced hepatoma using a battery of enzymes representative of different phases of ontogeny. None of the experimental tumors investigated exhibited an enzyme pattern consistent with any particular phase of ontogenesis. The data support the view that malignant transformation is associated with a kind of programming that is phenotypically characteristic for a particular tumor, but at the same time appears to reflect a disordered, abnormal pattern of gene expression.
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