Abstract
New pulse sequences for two-dimensional phase-sensitive detection of heteronuclear zero- and double-quantum coherence are presented for use with and without pulsed field gradients. The magnetization is phase modulated duringt1and then transferred to a proton for detection using a novel approach similar to the sensitivity-enhancement technique [Palmeret al. J. Magn. Reson.93, 151 (1991)]. These pulse sequences are useful for the measurement of size and relative sign of passiveJcouplings as well as for the measurement of the relaxation rates of zero- and double-quantum coherence. They can also be used as building blocks in multidimensional pulse sequences. The pulse sequences are tested on the peptide hormone motilin with a selectively13C-enriched α carbon.
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