Abstract
OPINION article Front. Hum. Neurosci., 02 February 2011 | https://doi.org/10.3389/fnhum.2011.00003
Highlights
The nature of the neural code remains a central issue of contention in neuroscience
In the many roles proposed for oscillatory activity, a uniting theme is the control of spike timing, which can broadly be considered on two timescales
Mounting experimental evidence suggests that phase codes are important in hippocampal processing but the establishment of such phase codes and their roles in information and memory processing are still unclear
Summary
The nature of the neural code remains a central issue of contention in neuroscience. Firing rate based schemes have dominated thinking for most of the past century, but there is a growing acceptance that temporal patterns of neuronal activity have an important role to play, at least in some systems and circumstances. As depolarizing drive increases further, the membrane potential reaches threshold slightly earlier on the oscillation, yielding a phase advance This intuition can be confirmed fairly using an analytical description of this system for a leaky integrate-and-fire (IF) model, at least to a first approximation, treating only a single spike on each cycle of the oscillation (Gerstner and Kistler, 2002; McLelland and Paulsen, 2009; for a more complete analytical account of oscillatory cycle locking behaviors, see Coombes and Bressloff, 1999). Several points are worth emphasizing (for a more detailed explanation, see McLelland and Paulsen, 2009): Frontiers in Human Neuroscience www.frontiersin.org
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