Abstract
This study was designed to investigate treatment efficacy and side effects of concomitant Aisu® (docetaxel) with three-dimensional conformal external beam radiotherapy for the treatment of inoperable patients with esophageal cancer. Inoperable patients were treated with three-dimensional conformal external beam radiotherapy (5/week, 2 GY/day, and total dose 60GY) plus docetaxel (30-45 mg/m2, iv, d1, 8). Twenty eight patients met the study eligibility criteria and the response rate was evaluated according to RICIST guidelines. Among 28 patients, 2 achieved CR, 22 PR, 3 SD and 1 patient was documented PD. Mild gastrointestinal reaction and bone marrow suppression were also documented. All treatment related side effects were tolerable. Three-dimensional conformal external beam radiotherapy combined with docetaxel is an active and safe regimen for inoperable patients with esophageal cancer.
Highlights
Materials and MethodsAccording to 2002 statistical estimation, agestandardized mortality of esophageal cancer (EC) in China was 21.6/105 for males and 9.6/105 for females, in contrast to 9.6/105 and 3.9/105 worldwide, 5.1/105 and 1.2/105 in the United States, 7.5/105 and 1.1/105 in Japan, for males and females, respectively (Song et al, 2012)
We focused on inoperative EC patients to observe if docetaxel combined with threedimensional conformal external beam radiotherapy is a proper choice
Among 28 patients, 18 patients accepted initial treatment whereas 10 cases recurrenced after operation or post-chemoradiation; 27 patients were squamous carcinoma and 1 adenocarcinoma; 16 were male and 12 female
Summary
Materials and MethodsAccording to 2002 statistical estimation, agestandardized mortality of esophageal cancer (EC) in China was 21.6/105 for males and 9.6/105 for females, in contrast to 9.6/105 and 3.9/105 worldwide, 5.1/105 and 1.2/105 in the United States, 7.5/105 and 1.1/105 in Japan, for males and females, respectively (Song et al, 2012). Even within China, a big geographic variation is observed where a higher incidence is documented in Henan, northern Jiangsu, and Shanxi province (Song et al, 2012). EC is usually diagnosed at advanced stage in this area with combined chemo- and/ or radio-therapy remaining a main treatment modality (Gu M., et al, 2013). Concurrent radio- and chemotherapy is considered a standard treatment for inoperable patients in this setting (Nishimaki et al, 2004). It is not known what combination is the best option. We focused on inoperative EC patients to observe if docetaxel combined with threedimensional conformal external beam radiotherapy is a proper choice
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