Abstract
Purpose: Progressive tumor growth is dependent on angiogenesis. Endogenous proteins that inhibit endothelial cell growth and that may play a physiological role in maintaining the normal low replication rate of vascular endothelial cells have been described. Among those are angiostatin, a 38 kD protein derived from plasminogen. Angiostatin is a potent inhibitor of angiogenesis, tumor growth, and metastasis, that was discovered during investigations into tumor dormancy, the process by which a primary tumor inhibits its remote metastases.
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