Abstract
5049 Background: IP epinephrine (EPI) has been shown to enhance the accumulation and antitumor activity of IP cisplatin (CDDP) in rats with peritoneal carcinomatosis (Duvillard et al., Int J Cancer, 1999). EPI activity was related to the vasoconstriction of the peritoneal vascular bed which limits CDDP peritoneal leakage and enhances drug penetration into tumor nodules. A phase I study was conducted to evaluate the local and systemic tolerance of IP EPI in association with IP CDDP. Methods: Between 02/2000 to 06/2003, 17 patients (pts) with refractory peritoneal carcinomatosis (15 ovarian, 1 colorectal, 1 mesothelioma; 1 M/16 F), median age of 64 years (range 52–77), PS 0–1, and normal organ and cardiovascular function were enrolled. CDDP (total dose of 100 or 120 mg), associated with increasing concentrations of EPI, was given intraperitoneally in 2 or 3 liters of saline solution over 3 hours. Plasma and peritoneal concentrations of EPI were determined by HPLC. Results: A total of 52 intraperitoneal cour...
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