Abstract
Twenty patients with unresectable cancer received ifosfamide as a 30 min i.v. infusion daily for 3 days. Dose limiting toxicity was seen in 6 patients and was genitourinary in 4, hematologic in 1, and CNS in 1. Leukopenia was seen in 10 patients, and microscopic hematuria in all except 4 patients. Divided dose administration enabled a larger total dose of drug to be given per treatment course, but did not change the genitourinary nature of the dose limiting toxicity when compared with a high single dose regimen. Total urinary alkylating activity was slightly less following the divided dose administration. For the 3 day divided dose schedule, a daily dose of 2400 mg/m 2 appears to be the maximally tolerated dose.
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