Phase equilibria of the binary systems of fenofibrate and dense gases (carbon dioxide, propane, trifluoromethane)

Abstract

The purpose of this work was to investigate phase equilibria, namely equilibrium solubility and melting point depression of fenofibrate in several dense gases (carbon dioxide, propane, trifluoromethane). The equilibrium solubility of fenofibrate in sub- and supercritical gases was measured using a static-analytical method at temperatures of 303.15 K, 323.15 K and 338.15 K in the pressure range from 0.10 MPa up to 35 MPa. In general, the solubility of fenofibrate in gas rich phase increases with increasing pressure at a constant temperature. The highest solubility of fenofibrate was observed in the presence of propane at all investigated temperatures. In addition, an empirical correlation based on Gordillo model was employed to estimate the experimental data. For determining the melting point of fenofibrate under pressured gas, a modified capillary method was applied in the pressure range from 0.10 MPa to 41 MPa. A melting point depression with a temperature minimum in the p,T - projection of the SLG line has been noticed for all of the investigated systems.