Abstract
The effects of calcium on the thermodynamic parameters of dipalmitoyl-phosphatidylserine (DPS) bilayers in the presence of 1 atm nitrogen and cyclopropane was investigated calorimetrically. It found that at pH 3.1, in the absence of calcium, cyclopropane produces two endothermic phase transitions, at temperatures 63.0° and 60.5°, as compared to the single endothermic transition that was found in the presence of nitrogen. The enthalpies of the cyclopropane transition were also reduced. In the presence of calcium and nitrogen the transition temperature was 66.5°. Upon substituting cyclopropane for nitrogen two endothermic transitions were observed. The main peak remained at 66.5° while the second peak melted at 58.0°. This lower peak melts at about the same temperature as the calcium free dispersion in the presence of cyclopropane. Thus, in the presence of an inert gas, the ionic environment of a lipid can moderate the effect a particular iner; gas may have. Moreover, the presence of an inert gas can cause calcium to apparently dissociate from the bilayer to form a separate calcium free phase.
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