Abstract

The enrichment and separation of trace compounds, as well as the preparation of nanomaterials, are all greatly facilitated by responsive micro-emulsion. A multi stimuli-responsive ionic liquids-based micro-emulsion system was established with alkyl-N-Tropine (trans) P-methoxycinnamate ([CnTr][PMCA], TILS) as a surfactant. The factors affecting the phase behavior of micro-emulsion, such as the structure of the TILS, cosurfactant, oil, temperature, pH, and salinity, were investigated by multiple research methods. Five zones were identified inside the micro-emulsion phase region as O/W, B.C., liquid crystal (L.C.), L.C.+B.C., and W/O. The TILS-based micro-emulsion displayed high stability at measured temperatures. High salinity contributed to a higher water solubilization capacity of the micro-emulsion. For the potential applications of the micro-emulsion, with sizes ranging from 20 to 70 nm, nanoscale silica particles showed persistent stability. High levels of drug loading rate (about 8.6 mg·g−1) and encapsulation efficiency (about 99%) of the micro-emulsion loaded with curcumin were attained.

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