Phase 2 trial design of BMS-986278, a lysophosphatidic acid receptor 1 (LPA1) antagonist, in patients with idiopathic pulmonary fibrosis (IPF) or progressive fibrotic interstitial lung disease (PF-ILD)

Tamera J Corte,Giridhar S Tirucherai,Edgar D Charles,Xiaojiang Zhan,Toby M Maher,Hideaki Watanabe,Aryeh Fischer,Hong Xiao,Brandon Elpers,Jonathan G Goldin,Jeffrey J Swigris,Takafumi Suda,R Adam Smith,Takashi Ogura,Lisa Lancaster,Anne Minnich,Scott M Palmer

doi:10.1136/bmjresp-2021-001026

Phase 2 trial design of BMS-986278, a lysophosphatidic acid receptor 1 (LPA1) antagonist, in patients with idiopathic pulmonary fibrosis (IPF) or progressive fibrotic interstitial lung disease (PF-ILD)

Tamera J Corte, Giridhar S Tirucherai + Show 15 more

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https://doi.org/10.1136/bmjresp-2021-001026

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Journal: BMJ Open Respiratory Research	Publication Date: Dec 1, 2021
Citations: 32	License type: open-access

Affiliation: Royal Prince Alfred Hospital, University of Sydney, Bristol-Myers Squibb (United States), University of Southern California, University of California, Los Angeles, Reva Medical (United States), National Jewish Health, University of Colorado Denver, Hamamatsu University School of Medicine, Kanagawa Cardiovascular and Respiratory Center, Vanderbilt University Medical Center, Clinical Research Institute

#Progressive Fibrotic Interstitial Lung Disease #Lysophosphatidic Acid Receptor 1 + Show 8 more

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IntroductionIdiopathic pulmonary fibrosis (IPF) and non-IPF, progressive fibrotic interstitial lung diseases (PF-ILD), are associated with a progressive loss of lung function and a poor prognosis. Treatment with antifibrotic agents can...

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