Abstract
Introduction Pharmacovigilance is not new to India and has in fact been going on since 1998. Adverse drugs reaction (ADRs) are important causes of morbidity and mortality all over the world. They account for approximately 10-20% of all hospitalized patients. The overall incidence of serious ADRs is 6.7% and that of fatal is 0.32%.Objective The objectives of the study was to find the pattern of adverse drug reactions in patients attending medicine ward of a tertiary care center of New Delhi.Methodology A prospective study was conducted from March 2013 to December 2013. On the basis of WHO-UMC causality assessment algorithm, the incidence and pattern of ADRs were assessed from 300 patients of 18 to 70 years of age. The collected data was entered in Microsoft Excel, Common Terminology Criteria for Adverse Events (CTCAE) and analysed by SPSS.Results The incidence of ADRs was found to be 13.67%. More than one ADRs has been reported from some patients. The gender of the patients has no significance in the occurance of ADRs (p=0.194). Highest number of ADRs were found in gastrointestional system followed by central nervous system. Gastrointestional ADRs were must commonly associated with the uses of antimicrobials. The most frequently seen ADRs were diarrhea, gastritis, abdominal pain followed by nausea and vomiting. Decreased level of consciousness (sedation, drowsiness) followed by dizziness and tremors were the frequent ADRs related to the central nervous systems. Based on WHO-UMC causality assessment algorithm, it was observed that a total of 57 ADRs were possible and 2 were probable. No other causality assessment category was observed.Conclusion The ADRs incidence was common even in a tertiary care center. The Gastrointestional and central nervous system disorder were common. The concern of Pharmacovigilance should be initiated.Birat Journal of Health Sciences 2016 1(1): 61-64
Highlights
Introduction Pharmacovigilance is not new toIndia and has been going on since 1998
Gastrointestional Adverse drugs reaction (ADRs) were must commonly associated with the uses of antimicrobials
Based on World Health Organisation–Uppsala Monitoring Center (WHO-UMC) causality assessment algorithm, it was observed that a total of 57 ADRs were possible and 2 were probable
Summary
Introduction Pharmacovigilance is not new toIndia and has been going on since 1998. It has been estimated that every year around 1,06,000 people die in USA because of ADRs which makes these reactions fourth leading cause of death after heart diseases, cancer and stroke.[6] The estimated cost of mortality and morbidity related to ADRs in USA is more than $75 billion annually.[7] In 1893, the Lancet formed a commission that invited doctors in Britain and its colonies to report anesthesia related deaths This was done after a 15 year Hannah Greener died after administration of chloroform, a new anesthetic at that time.[8] This reporting system formed the fore-runner of today's spontaneous reporting system.[9] The study was conducted to analyse the pattern of observed Adverse Drug Reactions using World Health Organisation–Uppsala Monitoring Center (WHO-UMC) Causality Assessment Algorithm in medicine ward of All India Institute of Medical Sciences (AIIMS)
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