Abstract
糖尿病患者是下肢动脉病变(又称周围动脉病变,PAD)的高危人群.一项在美国基层医院的大型横断面研究,前瞻性评估年龄≥70岁或年龄在50～69岁有吸烟或糖尿病史的患者的PAD的发生率,结果显示该人群中PAD检出率为29％[1].我国50岁以上的合并至少1项心血管危险因素的糖尿病人群中的临床研究证实,约有20％合并PAD[2].PAD是全身动脉硬化的一个标志,不仅发病率高,死亡率也高,PAD患者5年病死率为70％ ～ 80％.70％以上的PAD患者合并心、脑血管病变.2007年跨大西洋周围动脉诊疗的多学会专家共识及2010年中国2型糖尿病防治指南均指出:PAD的治疗目的包括改善患者下肢缺血症状以及降低患者的发生心血管事件的风险.对于体力活动明显受限的患者,治疗的主要目标是缓解症状,改善运动耐量,主要的内科药物如下。
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