Pharmacotherapeutic Effect of Stress Protectors in the Age Aspect

Abstract

The data of the literature and the results of original experimental observations concerning the age aspects of stress reactions that accompany a person from birth to adulthood are given. Stress in children is emotional and is characterized by an increase in the thymus, as well as an increase in the level of corticosteroids in the blood, as a reflection of the innate immune-lymphoid defense of the child, which occurs in the process of the childbirth stress of mother. Other indicators of neurohormonal protection (adrenal glands, spleen, eosinopenia, hyperglycemia) are typical but less pronounced than in adults due to functional immaturity of systems and organs. The shift in the balance of the prooxidant-antioxidant system is not marked. In addition, child stress is manifested by deficiency of magnesium ( Mg 2+ ), a violation of the acid balance and immune deficiency. The above data serve as the basis for the proof of the need of involving in everyday complex therapy of any disease, depending on the indications, along with formulary preparations in children's doses of herbal sedatives (Valeriana officinalis, Cardamine pratensis), psycho-responsive tranquilizers and even neuroleptics, magnesium preparations, Echinacea in combination with Zinc and vitamin C. Also antioxidants, immunostimulants and stressors (piracetam, aminolon, taurine), plant adaptogenes (Panax, Eleutherococcus), which prevent a stress reaction, without violating the level of innate protection of the growing organism and the child's mental abilities at the level of its physical development, are recommended.