Abstract
Sodium sulfanilylsulfanilate, a derivative of sulfanilamide, was first used therapeutically by Dochez and Slanetz1 against a fatal infection in ferrets supposed to be due to and resembling dog distemper. Maclntyre and Montgomerie2 in England employed this drug unsuccessfully in infections due to the distemper virus described by Carre-Laidlaw-Durkin. Oakley3 used it without benefit in experimental influenza. Coggeshall4 tested sodium sulfanilylsulfanilate in avian malaria. Hebb, Sullivan, and Felton5 recommended sodium sulfanilylsulfanilate and sodium sulfanilate for the treatment of lymphopathia venereum. This report deals with the pharmacology and toxicity of sodum sulfanilylsulfanilate.Sodium sulfanilylsuilate was determined by the Marshall6 method using alpha dimethylnaphthylamine in alcoholic solution as the coupling component. Determinations were made on whole blood, urine, and fecal discharges. The fate of single and repeated doses were studied in some normal subjects and in patients, following oral...
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