Abstract
Intravenous administration of β-carboline-3-carboxylate methyl ester (β-CCM) produced convulsions at small doses (0.03 mg kg ) in adult chickens, homozygous for the epileptic gene. Non-epileptic heterozygote hatchmates (carriers) did not undergo seizures at doses of 1 mg kg , and doses of 3–5 mg kg produced only brief myoclonic responses. The convulsant effect of β-CCM could be prevented by pretreatment with large doses of β-carboline-3-carboxylate propyl ester (β-CCP). β-Carboline-3-carboxylate methyl ester displayed a higher affinity than diazepam in displacement studies on synaptosomal membrane preparations from brains of epileptic and carrier chickens.
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