Abstract
Cough is the most common respiratory complaint for which medical attention is sought and often presents as the first and most persistent symptom of many respiratory diseases. Treatment options are limited. Despite its importance our understanding of the mechanisms which provoke cough is poor. The respiratory tract is innervated by sensory afferent nerves which are activated by mechanical and chemical stimuli. Activation of capsaicin-sensitive C-fibres and acid-sensitive, capsaicin-insensitive mechanoreceptors innervating the larynx, trachea, and large bronchi regulate the cough reflex.
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