Abstract
A series of eight alkylaminoethanol esters of p-ethoxybenzoic acid were examined for local anesthetic activity on the rabbit cornea and frog sciatic nerve, for acute toxicity in mice, for irratancy on the rabbit cornea and by the trypan blue test in rabbits, and for their spasmolytic activity on the isolated rabbit ileum. In general, sciatic nerve block was hastened, irritancy was increased, acute toxicity increased, and duration of topical anesthesia decreased as the alkylamino portion of the molecule was enlarged. A series of eight alkylaminoethanol esters of p-ethoxybenzoic acid were examined for local anesthetic activity on the rabbit cornea and frog sciatic nerve, for acute toxicity in mice, for irratancy on the rabbit cornea and by the trypan blue test in rabbits, and for their spasmolytic activity on the isolated rabbit ileum. In general, sciatic nerve block was hastened, irritancy was increased, acute toxicity increased, and duration of topical anesthesia decreased as the alkylamino portion of the molecule was enlarged.
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