Pharmacology of 5-HT2 Receptors

Abstract

The molecular mechanisms by which drugs bind to and regulate G-proteincoupled receptors (GPCR) remains a major unsolved problem for modern molecular biologists, biochemists and structural biologists. Ideally, we would like to ultimately define drug binding at the atomic level. An ideal molecular model would also be able to demonstrate why it is that agonists activate receptors while antagonists, which may or may not bind in overlapping domains, do not activate receptors. A perfect molecular explanation of drug action would elucidate the molecular determinants responsible for cellular regulation processes (e.g. desensitization, internalization and downregulation). At the present time, there are no verifiable models which elucidate these properties for any G-protein-coupled receptor.KeywordsAtypical Antipsychotic DrugD120N MutationLysergic Acid DiethylamideTypical Antipsychotic DrugHelical ArrangementThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.