Abstract
Clinical usage of erythromycin 1 and propionyl erythromycin ester 2 has confirmed the low toxicity in experimental animals as reported from these laboratories. Propionyl erythromycin ester lauryl sulfate 3 (PELS) has been found to have very low water solubility and is easily usable in pleasantly flavored suspensions. Chronic toxicity studies in rats and dogs have demonstrated the absence of visceral or hematopoietic damage following large doses for over three months. Oral administration of PELS produced higher serum concentrations in rats than propionyl erythromycin. Both antibiotics are mainly absorbed from the intestine of rats and excreted in very small quantities in the bile. High concentrations of erythromycin activity were found in the lung, spleen, liver, kidney, and heart after oral administration. The results of absorption studies using S 35 labeled PELS will be discussed.
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