Abstract
Abstract. Various antiparasitic drugs belonging to several pharmacological groups were tested by bath administration for in vivo activity against a natural infestation of rainbow trout. Oncorhynchus mykiss (Walbaum), by he flagellate protozoan Ichthyobodo necator. Fish were also monitored for signs of drug toxicity. Complete elimination of infestation in all fish was achieved only by bithionol (25 mgl‐1 for 3h on two consecutive days). Ketoconazole, toltrazuril, amprolium, sulphaquinoxaline, quinacrine, N‐metylglucamine, chloroquine, 1,3‐di‐6‐quinolylurea, diminazene aceturate and paromomycin were not effective. Diminazene aceturate (100 mgl‐1, 3h) was the only drug which was clearly toxic. The comparison of the response of symptomatic and asymptomatic infested fish to a formaldehyde bath indicates that poor health caused by I. necator may greatly increase the susceptibility of fish to the toxic effects of a drug or chemical.
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