Pharmacological therapy of white muscle disease in lambs with selenium preparations in a comparative aspect

Abstract

In the course of the experiment on the comparative assessment of selenium-containing preparations selephlan and plexomin Se-2000 in the treatment of white muscle disease in young sheep, it was determined that selephlan has a more pronounced effect on the clinical and physiological state and intestinal biocenosis of lambs, their morphological and biochemical blood parameters, as well as the level of antioxidant protection of the body of animals. Under the influence of the preparation, the erythro- and hematopoiesis is activated in lambs, as well as the normalization of biochemical blood homeostasis. The level of enzymatic activity (AST, ALT, ALP, LDH) significantly decreases in 1.36 (p≤0.05); 1.71 (p≤0.001); 1.21 (p≤0.05) and 1.3 (p≤0.01) times, while the concentration of carotene increases in 3.1 times, vitamin E increases in 1.73 times and vitamin A increases by 26.8%. Selephlan helps to reduce the concentration of DC by 21.8%, KD – by 28.7%, MDA – in 1.61 (p <0.05) times.