Pharmacological Targets for Neurorehabilitation

Abstract

In respect to the functional activities of D-cycloserine scientists suggested anticonvulsive activities [4,5] and furthermore the application seems to improve memory and cognitive function. Recently we discovered that D-Cycloserine has the ability to block kynurenic acid synthesis [6]. Kynurenic acid, a metabolite along the kynurenine pathway of tryptophan degradation blocks the glycine sites of NMDA glutamatergic receptors [7] and also the nicotine cholinergic receptors [8] and exerts anticonvulsive activities [7].