Pharmacological study of stable potassium iodide (KI) repeated prophylaxis in adult rats

Guillaume Phan,Céline Bouvier-Capely,Valérie Renaud-Salis,Rym Chioukh,David Suhard,Jean-René Jourdain,Thibaud Sontag,Floriane Carpentier,Alexandre Legrand,Charlotte Moulin,François Rebière,Maâmar Souidi,Michelle Agarande,J.-M Bertho,C Dinocourt,F Ecrabet,C Salhab,F Menetrier,S Le Hir

doi:10.1051/bioconf/20191406006

Guillaume Phan, Céline Bouvier-Capely + Show 17 more

Open Access

https://doi.org/10.1051/bioconf/20191406006

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Abstract

Pharmacological study of stable potassium iodide (KI) repeated prophylaxis in adult rats

Highlights

Ingestion of stable iodine, mainly as potassium iodide (KI) tablets, is the only medical countermeasure available to prevent the binding of radioactive isotopes of iodine to the thyroid and to protect the gland from the occurrence of cancer
The thyroids were dissected 1 hour after exposure to I-125 and the total radioactivity of I-125 was determined by gamma counting.The plasma stable iodine concentration as a function of the time after oral single dose of 1 mg/kg KI was measured by inductively coupled plasma mass spectrometry (ICPMS X Series II and iCAP Q, Thermo Electron) (n=6 per time point)
A dose regimen consisting of 1 mg/kg daily during 8 days was tested in rats (n=4 per time point) and verified through iodine plasma measurements at different times during the treatment

Summary

Introduction

Mainly as potassium iodide (KI) tablets, is the only medical countermeasure available to prevent the binding of radioactive isotopes of iodine to the thyroid and to protect the gland from the occurrence of cancer. The nuclear reactors accidents at Fukushima in 2011 showed that the populations could be exposed to prolonged or repeated releases of radioisotopes of iodine for more than one week. In such situations, prolonged KI prophylaxis could be considered but no indication is currently available regarding the conditions for implementing repeated doses of stable iodine. The aim of this work was to study the protective effect of different KI doses in the rats in order to select an optimal KI dose which could be implemented in repeated prophylaxis. The pharmacokinetic parameters of stable iodine were evaluated in the rats after oral ingestion of KI in order to model and assess a dose regimen for a repeated prophylaxis over 8 days

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