Abstract
AbstractThe effect of various pharmacological interventions on the collecting phase of cystometrogram (CMG) has been investigated by means of a new cystometric procedure in urethane‐anesthetized rats. The method involves the transvesical infusion, through a needle inserted in the bladder dome, of warm (37°C) saline at a rat (2.8 ml/h) simulating a maximal hourly diuresis value for this species. In these conditions bladder voiding is produced through the activation of a supraspinal vesico‐vesical reflex. Either chemical (6‐hydroxydopamine, reserpine) or surgical (section of hypogastric nerves) sympathectomy produced a picture of detrusor hyperreflexia and urine dripping, mimicking cystometric finding of human disease. This new procedure may be useful for screening and development of new drugs for treatment of urinary incontinence.
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