Pharmacological studies of some traditional Chinese medicines on gastric functions. (2) The effects of oren-gedoku-to (OGT), san'o-syasin-to (SST), antyu-san (AS) and dai-saiko-to (DST) on gastric acid secretion in rats

Abstract

The effects of OGT, SST, AS and DST on gastric acid secretion stimulated by histamine, pentagastrin, carbachol and 2-deoxy-D-glucose (2-DG) were studied in the perfused stomach of anesthetized rats, and these effects were compared with those of cimetidine, 16,16-dimethyl-prostaglandin E2(DMPGE2) and atropine. OGT and SST showed little or no effect on the acid secretion induced by histamine or carbachol at doses of 100 mg/kg, whereas the former showed a moderate inhibition and the latter showed a marked one against pentagastrin-stimulation. AS and DST had no effect on the acid secretion induced by carbachol at doses of 100 mg/kg, whereas they showed a moderate inhibition against histamine-stimulation, and the latter showed a significant inhibition against pentagastrin-stimulation. Further, each of the above four drugs showed a significant effect on 2-DG-stimulation. Cimetidine (1-10 mg/kg) inhibited gastric acid secretion stimulated by histamine, pentagastrin, carbachol or 2-DG in a dose-dependent manner. Similarly, DMPGE2 (10 micrograms/kg) strongly inhibited acid secretion induced by the four secretagogues. Atropine (50 micrograms/kg) inhibited acid secretion induced by carbachol or 2-DG, but not that by histamine or pentagastrin. These results suggest that OGT, SST, AS and DST clearly affect the mechanism of gastric acid secretion, and the site of action of OGT may differ from those of SST, AS and DST.