Abstract
Abstract: Thiazole and the related nuclei constitute one of the most significant moieties in the extensively emerging domain of heterocyclic compounds. The versatile nature of the thiazole nucleus can be determined as it is present in natural products like vitamin B1. Furthermore, its derivatives exhibit diverse biological activities, including antimicrobial, anticancer, antihistaminic, antioxidant, etc. They have also emerged as potent CNS agents and are primarily used in the treatment of various CNS disorders. The structure-activity relationship of various amine derivatives of ethylated thiazole demonstrates their use as potential agents in the treatment of melanoma, pigmentation as well as solar elastosis. Thiazole fused with different heterocyclic systems results in many novel derivatives with higher therapeutic activity. Benzothiazole and Thiazolopyrimidine have a distinct position in this regard. This review focuses on the central role of thiazole and its derivatives in current drug design, covering a broad spectrum of pharmacological activities associated with them.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
