Pharmacological screening of Anti-inflammatory and Analgesic activity of Apigenin in Mice Model

Abstract

Introduction: Apigenin is a flavonoid found in many fruits and vegetables as well as in Chinese medicinal herbs. This study aimed to assess the anti-inflammatory and analgesic effects of Apigenin. Materials and Methods: Carrageenan-induced mouse paw edema was used to assess anti-inflammatory activityand Eddy's hot plate analgesiometer was used to assess analgesic activity. Results and Discussion: Apigenin at dosages of 25 mg/kg and 50mg/kg body weight significantly reduced Carrageenan-induced paw edema by 41.21% (3–9 h) and 61.4% (3–9 h), respectively. Apigenin 25mg/kg and 50mg/kg body weight produced significant dose-response analgesic activity in the hot plate test. Conclusion: The findings in this study suggest that Apigenin possesses anti-inflammatory and analgesic activities in a dose dependent manner.