Abstract
With the growing need to develop effective and sustainable therapeutic alternatives, research has been focusing on the association of products of natural origin with nanotechnology, which besides enhancing the action, acts to protect the constituents from degradation. A fruit highlighted in research today is Astrocaryum vulgare (Tucuma), as well as natural fixed oils extracted from seeds, such as grape seed oil and microalgae biomass. The present study aimed to evaluate the parameters of pharmacological safety and in vitro hemocompatibility of lipid nanocarriers (CLN) from the association of tucuma butter with two oils (grape seed and microalgae). Hemocompatibility rates were assessed by analyzing hemolytic activity, in addition to clotting time and clot retraction, whereas pharmacological safety analyzed parameters such as cell viability, DNA damage, dichloride and nitric oxide production. The nanocarriers produced through the association of butter with oils showed a satisfactory pharmacological safety and hemocompatibility profile.
Highlights
Studies combining natural bioactive agents such as natural oils and nanotechnology are being carried out as adjuvants in therapeutic processes, such as healing and antimicrobial action
Grape seed oil is known for its great richness in vitamin E, vitamin C, β-carotene in addition to matter rich in tocopherols, steroids and various fatty acids, acting as a fat-soluble antioxidant in plasma and the tissue membrane, protecting cell integrity
Through the characterization of the nanoparticles it was possible to observe that at time 0, that is, on the day of manufacture, formulation 1 consisting of Tucumã butter and grape seed oil showed a monodispersed distribution of particles with an average value of PDI 0.260 where according to the literature the ideal value is
Summary
Studies combining natural bioactive agents such as natural oils and nanotechnology are being carried out as adjuvants in therapeutic processes, such as healing and antimicrobial action. Due to its great richness in medicinal plants, has been standing out in the use of Astrocaryum vulgare butter (Tucumã). Tucumã, which is used for food and beauty, is considered a rich source of bioactive substances, with high lipid content, large amounts of carotene, precursor to vitamin A, high levels of fiber and vitamin E. Grape seed oil is known for its great richness in vitamin E, vitamin C, β-carotene in addition to matter rich in tocopherols, steroids and various fatty acids, acting as a fat-soluble antioxidant in plasma and the tissue membrane, protecting cell integrity. Grape seed stands out for being a source of linoleic and oleic acid, containing traces of linolenic and palmitoleic. Linoleic acid and linolenic acid are essential for the proper functioning of various organs and are essential for maintaining cell membranes with normal functioning (CHOI; LEE, 2009; ANDRADE et al, 2012; MEDINA et al, 2015)
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