Abstract
Diabetes is a disorder of carbohydrate metabolism that requires immediate changes in lifestyle. Gestational diabetes (GDM) is defined as carbohydrate intolerance that begins or is first recognized during pregnancy, in both the conditions vitamin D play an important role in supporting pathogenesis. Vitamin D is regulated in the form of 25OHD from kidney to intestine and to the blood. Vitamin D and pro drug can protect against complications of diabetes like kidney failure, vision loss, hypertension and heart attack. Vitamin D receptors are present in both pancreatic beta-cells and immune cells. Beside its classical role as the major regulator for calcium absorption, it mediates the activity of beta-cell calcium- dependent endopeptidases promotes conversion of proinsulin to insulin and increases insulin output. In peripheral insulin target tissues, it enhances insulin action via regulation of the calcium pool. Its deficiency impairs insulin secretion and induces glucose intolerance. Vitamin D supplementation has shown to reduce the risk of developing type2 diabetes. Vitamin D intake is essential for maternal health and prevention of adverse outcomes. Circulating 25OHD concentrations reflect vitamin D status, and the normal range is between ~32 ng/ml and ~80 ng/ml, with values below ~32 ng/ml defined as deficient.
Highlights
Gestational diabetes mellitus (GDM) usually reveals itself in the latter half of pregnancy and it is identified by carbohydrate intolerance of variable severity [1]
Prevalence of severe vitamin D deficiency (
Another study demonstrated that a combined daily intake of 1200 mg of calcium and 800 IU of vitamin D lowered the risk of type 2 diabetes by 33% as compared with a daily intake of less than 600 mg of calcium and less than 400 IU of vitamin D [36]. 4000 IU vitamin D was administrated for 6 months to women with vitamin D less than 50 nm/Land median serum 25(OH)D3 increased significantly and insulin resistance and fasting insulin decreased [37]
Summary
Priyanka Shukla, Rahul Mishra, Wei Huang*, and Ning Hu 1Department of Orthopaedics, First Affiliated Hospital of Chongqing medical University, Chongqing, China Received date: 8 May 2015; Accepted date: 6 June 2015; Published date: 10 June 2015. Citation: Shukla P, Mishra R, Huang W, Hu N (2015) Pharmacological Role of Vitamin D Supplementation in the Prevention of Diabetes and Gestational Diabetes. J Diabetes Res Ther 1 (1): doi http://dx.doi. org/10.16966/2380-5544.104 Copyright: © Shukla P. et al This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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