Abstract
Currently, among chemical pollutants a significant danger to the health of animals and humans represent oxygen-containing nitrogen compounds nitrates and nitrites, which are widely used as mineral fertilizers. The article presents data on the study of chronic nitrate intoxication, reproduced in laboratory animals and its pharmacological correction with a complex of substances of phospholipid and polysaccharide nature. The introduction of sodium nitrate to non-linear rats for 30 days at a dose of 3.8 mg per animal leads to the development of intoxication in rats with dominant signs of liver damage. On this background, the use of the complex of beet fiber and rapeseed lecithin leads to a weakening of nitrate toxicosis, which is demonstrated by an increase in rats’ body weight, weakening of the clinical manifestations of intoxication, a decrease in cytolytic syndrome, intrahepatic cholestasis and impaired protein synthesis function of liver.
Highlights
Among chemical pollutants a significant danger to the health of animals and humans represent oxygen-containing nitrogen compounds - nitrates (NO3) and nitrites (NO2), which are widely used as mineral fertilizers [1]
Chronic nitrate intoxication was modeled by daily intragastric administration of sodium nitrate to rats for 30 days
The obtained data indicate that intoxication with sodium nitrate leads to an increase in the level of aminotransferases in the blood of laboratory rats, indicating damage to hepatocytes and the release of intracellular substances into the blood. This process is accompanied by the intrahepatic cholestasis and the violation of the protein-synthetic function of liver
Summary
Among chemical pollutants a significant danger to the health of animals and humans represent oxygen-containing nitrogen compounds - nitrates (NO3) and nitrites (NO2), which are widely used as mineral fertilizers [1].Numerous studies have found out that the widespread use of mineral fertilizers in agriculture without an adequate level of analysis of their content and timing of application creates a serious problem due to an increase of the nitrates and nitrites concentration in water, soil and plants. When studying the degree of contamination of fodder plants with nitrates and nitrites in 15 farms located in the northern and central climatic zones of Krasnodar region, most often the excess of the permissible concentration of nitrates and nitrites was registered in the green mass of perennial grasses and corn. The chronic effects of even low doses of nitrite cause negative effects on animal health, which include inhibition of the mechanisms of natural resistance, violation of reproductive function, respiratory tract disease, damage of the nervous system, decreased productivity and safety [3, 4]
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