Abstract
Abstract Isoidide dinitrate is a more active vasodepressor agent in anaesthetised animals than either of its geometric isomers, isosorbide dinitrate and isomannide dinitrate. Isoidide dinitrate also has the greatest vasodilator action of the three isomers on the vascular system of the dog hind leg and is a more potent hypotensive agent than isosorbide dinitrate in hypertensive rats. The greater activity of isoidide dinitrate may be attributable to its higher oil: water partition coefficient or enhanced drug-receptor interaction resulting from the spatial positions of the nitrate groups or both factors. No evidence was found for involvement of adrenergic receptors in responses of vascular or intestinal smooth muscle to isoidide dinitrate.
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