Abstract
The effect of certain drugs on the nialamide + 2,4,5-trihydroxyphenylalanine (6-OH-dopa) induced degeneration of central noradrenaline (NA) neurons has been investigated by measuring the uptake in vitro of 3H-NA in mouse brain slices. Nialamide + 6-OH-dopa treatment led to a more pronounced reduction of 3H-NA uptake in the cerebral cortex than in the hypothalamus, indicating that the NA nerve terminals in the cerebral cortex are more sensitive to 6-hyroxydopamine (6-OH-DA). Reserpine was ineffective in modifying the neurotoxic effects, although a small protective effect was seen in the hypothalamus. Similar results were obtained when uptake of 3H-metaraminol was measured. Both desipramine (DMI) and amphetamine could counteract the nialamide + 6-OH-dopa induced degeneration, which in the case of DMI was almost complete. Inhibition of catechol- O-methyl transferase (COMT) by 4-tropolone acetamide led to a small potentiating effect. There were no significant effects on the 3H-DA uptake in nucleus caudatus indicating that the dopamine (DA) nerve terminals in this region were unaffected.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
