Abstract
Spiral-type reentry is a principal mechanism for the genesis of life-threatening ventricular tachyarrhythmias. We investigated differential effects of Na channel blockers, IKr blocker (nifekalant), ICa,L blocker (verapamil), and amiodarone on the spiral reentry in rabbit hearts by using a high-resolution optical mapping system. Two-dimensional subepicardial layer of left ventricular myocardium with uniform anisotropy was prepared by endocardial cryoablation. During ventricular tachycardia (VT) elicited by cross-field stimulation, spiral-type excitations rotating around functional block lines (FBLs) were visualized.
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