Abstract
The triggering mechanisms involved in the evocation of rumination remain unclear. Pharmacological agents such as volatile fatty acids, catecholamines, gastric hormones, opioids and autacoids have been used to examine the physiological mechanisms involved in evoking rumination. Alpha-2 adrenoreceptor agonists, pentagastrin and serotonin have been found to evoke rumination. Naloxone facilitated the evocation of rumination by adrenaline. The exact means whereby these pharmacological agents exert their effects have not yet been determined.
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