Abstract
Objective: This study was undertaken to screen the effect of administration of various doses of hydroethanolic extract of unripe fruit of Carica papaya L. (HEECP) against Dalton’s ascitic lymphoma (DAL) in Swiss albino mice.Methods: DAL cells were injected intraperitoneally (1×106 cells) to each mouse and divided into various groups. The animals were treated with various doses (200 mg/kg and 400 mg/kg) of HEECP. A standard drug (5-fluorouracil, 20 mg/kg/day) was also used. The animals were evaluated for hematological and biochemical parameters and were compared with the same parameters in the standard by collecting blood from a retro-orbital blood vessel of mice. Results: The life spans of the animals were increased. In the DAL tumor control group, the average life span of animals was found to be 45% whereas, 200 and 400 mg/kg of test drug showed increase in life span to 67% and 75%, respectively. Platelets count was significantly (p<0.001) decreased in cancer control group and was brought back to normal after treatment. Conclusion: These observations suggest that the extract possesses antineoplastic effect against DAL.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Asian Journal of Pharmaceutical and Clinical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
