Pharmacological evaluation of anti-anemic property of aqueous extracts of Falcaria vulgaris leaf in rats

Abstract

In the last decade, traditional medicine has been used to treat several diseases such as hemolytic anemia. One of these plants is Falcaria vulgaris. This plant is expanding vastly in Iran. In this experiment, we assessed the anti-anemic property of aqueous extract of F. vulgaris leaf. After collection of the plant, its extract was obtained using Soxhlet extractor. In vivo design, after 1 day of the last injection of Phenylhydrazine, the rats were divided into six subgroups, including negative healthy control, untreated negative control, and four groups receiving the F. vulgaris at 25, 50, 100, and 200 mg/kg concentrations. At the end of day 15 of treatment, the animals of all groups were euthanized and blood samples were drawn immediately from the animals’ hearts to analyze the hematological and biochemical parameters. The data were analyzed by SPSS-21 software. All doses of aqueous extract of F. vulgaris leaf (especially FV200) significantly (p ≤ 0.05) increased the levels of body weight, WBC, neutrophils, platelet, RBC, Hb, PCV, MCV, MCH, MCHC, and decreased the raised levels of ALP, AST, ALT, GGT, urea, creatinine, ferrous, ferritin, and erythropoietin as compared to the untreated group. Finally, the results showed the useful anti-anemic property of F. vulgaris leaf aqueous extract.