Pharmacological Effects of Verticine: Current Status.

Zhenhua Yin,Wei Zhang,Lin Chen,Wenyi Kang,Juanjuan Zhang,Qingfeng Guo

doi:10.1155/2019/2394605

Abstract

Verticine is the major bioactive constituent of Fritillaria as a kind of Traditional Chinese Medicine. Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expectorant, sedative, and analgesic activities, in addition to inhibiting proliferation of cultured orbital fibroblast, angiotensin converting enzyme (ACE), and acetylcholinesterase (AChE) and inhibiting hERG potassium channels. The underlying mechanisms of verticine are still under investigation. This review will comprehensively summarize the metabolism, biological activities, and possible mechanism of verticine.

Highlights

Verticine (Figure 1) belongs to a kind of isosterol alkaloid, is the major bioactive constituent of Fritillaria as Traditional Chinese Medicine that is widely used as an antitussive and expectorant [1]
Pharmacokinetics of verticine is closely related to its biological activity, and the metabolism is influenced by the mode of administration, sex, and animal types
The V1/F was 40.832 L/mg, indicating that verticine was mainly distributed in blood, intracellular fluid, Table 1: The pharmacokinetics of verticine in references

Summary

Introduction

Verticine (Figure 1) belongs to a kind of isosterol alkaloid, is the major bioactive constituent of Fritillaria as Traditional Chinese Medicine that is widely used as an antitussive and expectorant [1]. Pharmacological researches on verticine have reported its valuable benefits in a variety of diseases, especially its anticancer effect. The pharmacological effects, including metabolism, antitumor, antiinflammatory, protection against acute lung injury diastolic bronchus, inhibition of angiotensin converting enzyme, and acetylcholinesterase, antitussive expectorant, sedative analgesia, were summarized, which provides theoretical references for its clinical application

Metabolism

Pharmacological Effects

Findings

Conclusions